Sildenafil Citrate

viagra over the counterHave you ever heard about it? Sildenafil citrate is included in many ED meds, and this means that it’s often used to treat impotence (Viagra) in addition to pulmonary arterial hypertension (Revatio).

Brief History

Its number one treatment for erectile dysfunction nowadays, but this medication was initially designed by scientists as hypertension treatment and a drug that cures angina pectoris. However, during trials researchers noticed that Sildenafil Citrate didn’t prevent angina, but it induced marked penile erections. It was the first oral treatment for ED in the US when it hit the market in 1998.

Mechanism of Action

All penile erections are caused by filling a penis with enough blood, and it happens when the vessels responsible for delivering the blood to penile tissues start increasing its delivery, while the vessels that carry the blood away from these tissues reduce its removal. When it comes to normal conditions, sexual arousal and stimulation result in production and release of nitric oxide in the penis. This chemical activates guanylate cyclase, the enzyme that results in producing cGMP. The latter one is responsible for having a firm erection because it affects the amount of blood delivered and removed by penile vessels.

Sildenafil Citrate works by inhibiting the enzyme, PDE-5, which leads to destroying cGMP, and that’s why it’s called a PDE-5 inhibitor. This is how this medication prevents its destruction and allows it to accumulate and persist for a longer period of time. The longer it persists, the firmer and more prolonged your erections are.

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Usage of Meds That Contain Sildenafil Citrate to Treat ED

As a man, you may already know that Sildenafil Citrate is the active ingredient of many meds taken to treat impotence, or erectile dysfunction. It’s an oral medication that belongs to the group of PDE-5 inhibitors, thus, helping users keep and maintain their erections.

How do these ED meds work? Sildenafil Citrate works by boosting the blood flow into penile tissues, thus, resulting in getting and keeping a firm and lasting erection, but its intake requires enough sexual stimulation because it works only when you’re aroused. Another important detail is that the drugs that contain this ingredient don’t protect against STDs, such as hepatitis B and others.

viagra tablets reviewKeep in mind that cGMP is responsible for your erection because it affects the amount of blood that penile vessels remove and deliver. Sildenafil Citrate inhibits PDE-5, the enzyme that destroys cGMP, thus, allowing it to persist and accumulate for a longer period of time.

To solve your erection problems, you need to take the meds that contain Sildenafil Citrate orally, as needed, and according to the guidelines of your doctor. Most of them should be taken thirty minutes, but not more than a few hours, before your planned sexual intercourse. The most effective method is to take one pill one hour before a sexual activity, and it’s not allowed to overdose such ED meds.

They are available in different strengths, including 25 mg, 50 mg and 100 mg. It’s advisable to start with a lower dose, but your right dosage always depends on your health condition, individual response and other important factors.