How Sildenafil Citrate Treats Pulmonary Hypertension

Pulmonary hypertension is still one of those diseases that are quite hard to treat. Nowadays, there are many vasodilators, including inhaled nitic oxide infusions, but most of them are limited by their high cost or ease of use. The good news is that Sildenafil Citrate is an effective vasodilator designed to treat ED, and there are many trials that prove that it’s a great alternative to traditional treatment methods when it comes to dilating pulmonary vasculature. That’s because it provides patients with convenience, is affordable and has a few side effects.

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Mechanism of Action

Sildenafil Citrate belongs to PDE-5 inhibitors, and it works by improving vasodilatory effects of nitric oxide for patients who suffer from pulmonary hypertension because its intake prevents degradation of cGMP, thus, increasing the blood flow and promoting relaxation of vascular smooth muscles.
Pay attention to reliable human trials and animal models because they prove that the intake of Sildenafil Citrate can result in a relatively selective decrease in terms of pulmonary artery pressure, but the best part is that this effect is achieved without any unwanted symptoms, including systemic hemodynamic effects. Besides, inhibiting PDE-5 by this medication improves nitric oxide’s platelet anti-aggregator activity while preventing thrombus formation.


The initial dose of Sildenafil Citrate is 0.5 mg/kg that should be taken orally every 4-8 hours, while the maximum one is 2 mg/kg every four hours.